Leptin is well known for its role in maintaining energy balance by inhibiting hunger and limiting fat storage. This snapshot will explain how SNPs on the Leptin Receptor (LEPR) gene can alter our response to leptin: the Brain (CNS) – impacting appetite and learning, memory, and mood immune system – as an inflammatory messenger (like IL6), excess leptin can increase risk of hypertension, metabolic syndrome, cardiovascular disease and cytokine storm fertility – affecting ovulation, morning sickness and PCOS bone metabolism – fracture healing and osteoporosis and most importantly, what you can do about it – including sleep!